Russ Ferland, Ph.D.
Professor
COM生物医学科学系主席
Location
The combined long-term objectives of our research are to better understand the molecular, genetic, 以及导致神经发育和神经紊乱的细胞机制. Overall, my research interests lie primarily in the study of disorders of brain development and neurological disease, 具体涉及以下调查领域:
1) functional analyses of AHI1 and CSPP1, two novel genes which we mapped and cloned in individuals with Joubert syndrome (Hsiao et al., J. Neurosci., 2021; Munoz and Ferland, J. Cell Sci., 2019; Bourgeois and Ferland, Dev. Biol., 2019; Tuz et al., Am. J. Hum. Genet., 2014; Tuz et al., J. Biol. Chem., 2013; Westfall et al., J. Neurosci., 2010; Hsiao et al., Hum. Mol. Genet., 2009; Doering et al., J. Comp. Neurol., 2008; Ferland et al., Nature Genetics, 2004),
2) formation and function of the primary non-motile cilia in development and disease (Hua and Ferland, Methods Cell Bio., 2023; Hsiao et al., J. Neurosci., 2021; Munoz and Ferland, J. Cell Sci., 2019; Munoz and Ferland, J. Cell Sci., 2019; Bourgeois and Ferland, Dev. Biol., 2019; Hua and Ferland, Bioessays, 2018; Hua and Feland, Cell. Mol. Life Sci., 2018; Hua and Ferland, Cilia, 2017; Tuz et al., Am. J. Hum. Genet., 2014; Tuz et al., J. Biol. Chem., 2013; Hsiao et al., Cilia, 2012; Westfall et al., J. Neurosci., 2010; Hsiao et al., Hum. Mol. Genet., 2009),
3)癫痫阈值的遗传和神经解剖学机制, seizure propagation, epileptogenesis, 和癫痫猝死(SUDEP)(威尔逊, et al., FASEB J., 2021; Ferland et al., G3 Genes, Genom. Genet, 2017; Ferland, 2017; Loscher, Ferland, and Ferraro, Epilepsy and Behavior, 2017; Kadiyala et al., J. Neurosci., 2016; Kadiyala et al., Epil. Res., 2015; Kadiyala et al., PLoS ONE, 2014; Papandrea et al., Exp. Neurol., 2009; Papandrea et al., Epil. Res., 2009; Ferland et al, 1998a,b,c, 1999, 2002a,b, 2003).
Credentials
Education
Post-Doctoral Training
Harvard Medical School & 霍华德休斯医学研究所(波士顿,马萨诸塞州)
Research
Selected publications
Srinivasan A, Srinivasan A, Ferland RJ. AutoSholl允许独立于用户跟踪的Sholl分析自动化. 中华神经科学杂志,2016,31 (1):1-6. Source code & 编译版本的算法是可用的 at: http://github.com/ferlandlab/AutoSholl
Muñoz-Estrada J和Ferland RJ. Ahi1促进Arl13b纤毛招募, 调节Arl13b的稳定性,是正常细胞迁移所必需的. 中国生物医学工程学报,32(6):1145 - 1145.
- 这项工作在 F1000Prime, 5 Dec, 2018.
Hua K and Ferland RJ. 初级纤毛蛋白:纤毛和纤毛外的位置和功能. Mol. Life Sci., 75:1521–1540, 2018.
Srinivasan A, Muñoz-Estrada J, Bourgeois JR, Nalwalk J, Pumiglia K, Sheen V, Ferland RJ. BranchAnalysis2D/3D自动分析分支结构的形态. 中华神经科学杂志,2018,29 (4):1-6. Source code & 该算法的编译版本可在以下网址下载: http://github.com/ferlandlab/BranchAnalysis2D-3D
Hua K and Ferland RJ. 固定方法对纤毛蛋白免疫标记的影响不同. Cilia, 6;5: pp. 1-17, 2017.
肖玉春,张建军,张建军,等。主要纤毛的贩卖与贩卖. Cilia, 1:4 (1-13), 2012
刘建军,刘建军,刘建军,刘建军. 小鼠近交系氟基诱导的肌阵挛分析. Epil. Res., 87:130-136, 2009.
- 这项工作在 F1000 Prime, 31 Jul 2008.
Other scholarly activity
Book Chapters:
Löscher W,费兰RJ,费拉罗TN. 应变对癫痫发作和癫痫表达的影响. In: Models of Seizure and Epilepsy, 2nd edition, Cambridge: Academic Press (2017) pp. 21-38. ISBN 9780128040669
华坤,陈文杰,陈文杰. Joubert syndrome. In: Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier (2017) pp. 1-8. ISBN 9780128093245
Ferland RJ, Walsh CA. The genetics of Joubert syndrome: Insights into the development of the posterior midline of the brain. In: Squire, LR (Ed.神经科学百科全书. 圣地亚哥:学术出版社(2009)pp. 249-256.
陈志强,陈志强,陈志强. 鼻脑神经网络在点火后期的作用. 见:Corcoran, M和Moshe, S(主编).) Kindling 5. 纽约:Raven出版社(1998)pp. 151-165.
Invited Editorials:
Ferland RJ and Guerrini R. 结节性异位是建立在层次上的. 中国生物医学工程学报,30 (3):742-743,2009.
Ferland R and Hua K. Referee Report For: Murine Cep290 phenotypes are modified by genetic backgrounds and provide an impetus for investigating disease modifier alleles [version 1; referees: 2 approved] F1000Research 2015, 4:590 (doi: 10.5256/f1000research.7495.r10185)
Hua K and Ferland RJ. Primary cilia: the story of the hair-like organelle that signals just became more complicated. Atlas of science, 2019. http://atlasofscience.org/primary-cilia-the-story-of-the-hair-like-organelle-that-signals-just-became-more-complicated/